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Opioids inhibit NOS (Kampa et al., 2001), and this inhibition may need to be well-correlated with other effects of opioids (perhaps at NMDA coincidence detectors?) in order for the plasticity required for tolerance to occur

Scopolamine hydrobromide (#S~1875) was purchased from Sigma Chemical (St Louis, MO)

F., Morales, C

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